Piperazine skeleton in the structural modification of natural products: a review
Piperazine moiety is a cyclic molecule 30hh bikini containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms.Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications.Over 100 molecules with a broad range of bioactivities, including antitumor, antibacterial